Research overview

My research is in machine learning/data mining and natural language processing, with an emphasis on applications in health informatics.

For example, one of my major ongoing research aims concerns optimizing the processes of evidence-based medicine using novel natural language processing and machine learning methods. The aim is to reduce the (human) workload involved in conducting systematic reviews (i.e., making sense of the biomedical literature), so that we can realize the aim of evidence-based care in an era of information overload. An ongoing project in this direction is RobotReviewer.

More broadly, I am interested in core machine learning and natural language processing issues: e.g., structured and unstructured classification techniques; neural models; semi-supervised learning methods; learning from imbalanced data; and learning from alternative forms of supervision. I tend to be most excited by interdisciplinary research that motivates technical questions by way of interesting applications.

A random sample of semi-recent publications

Ryan Bridges, Jette Henderson, Joyce Ho, Byron C. Wallace and Joydeep Ghosh. Automated Verification of Phenotypes using PubMed Methods and Applications for Healthcare Analytics (MAHA) at ACM BCB; 2016.

Matthew Lease, Gordon V. Cormack, An Thanh Nguyen, Thomas A. Trikalinos, and Byron C. Wallace. Systematic Review is e-Discovery in Doctor's Clothing Medical Information Retrieval (MedIR) Workshop at the 39th International ACM SIGIR Conference on Research and Development in Information Retrieval; 2016.

An Thanh Nguyen, Byron C. Wallace, Junyi Jessy Li, Ani Nenkova and Matthew Lease. Aggregating and Predicting Sequence Labels from Crowd Annotations Association for Computational Linguistics (ACL); 2017.


06/16/2017 Upcoming talks

I'll be giving a talk at Weill Cornell Medicine as part of their Machine Learning in Medicine series on 7/14. I'll also be giving a keynote at the 4th International Symposium on Systematic Review and Meta-Analysis of Laboratory Animal Studies in August.

03/31/2017 Distinguished Clinical Research Informatics Paper Award at AMIA Joint Summits

Our paper, "PheKnow–Cloud: A Tool for Evaluating High-Throughput Phenotype Candidates using Online Medical Literature" was awarded the 2017 Distinguished Clinical Research Informatics Paper Award @ the AMIA joint summits. Joint work with Jette Henderson, Ryan Bridges, Joyce Ho and Joydeep Ghosh.

03/08/2017 SDM panel

I'll be serving on a panel at the annual Statistics and Data Mining (SDM) conference on Data mining, clinical medicine, and medical research: The current state and future of the nexus

09/13/2016 AHRQ grant funded

My AHRQ R03 grant, Hybrid Approaches to Optimizing Evidence Synthesis via Machine Learning and Crowdsourcing, has been selected for funding!


My work has been supported with grants from the National Institutes of Health, National Science Foundation, the Army Research Office, Seton hospital, Amazon and seed funds from Brown University.